Human Genomics - Research Associate

McGill University

Location: Quebec
Date posted: 2014-01-28

Research Associate for McGill Epigenome Mapping Centre

A Research Associate will join a multidisciplinary team of biologists, genomicists, and bioinformaticians within the McGill Epigenome Mapping Centre (EMC) carrying out research in the next frontier in human genomics, exploring its tissue specific function and the impact of the environment on the genome. The EMC was established by the CIHR Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC) as one of two National Epigenomic Mapping Centres, and will operate under the principles of the International Human Epigenome Consortium (IHEC). The McGill EMC is housed in the McGill University and Génome Québec Innovation Centre (Montreal, Canada), a world-class research facility for genomics and bioinformatics located on McGill University's main campus. The facility holds a number of high-throughput sequencing technology platforms, automated laboratory processes, and large-scale computing supporting an array of genome-wide epigenome mapping techniques (including MethylC-seq, ChIP-seq, RNA-seq).

The project aims at mapping epigenetic marks (methylation, histone marks, gene expression) in healthy and patient-derived human tissue samples, and linking epigenetic variation to environmental, genetic and phenotypic variation. The appointment will be in the Department of Human Genetics.

Duties/Responsibilities: The primary duties of the research associate (RA) will be to oversee lab operations of the EMC, from communication with numerous international collaborators to procure hundreds of tissues and cell types from normal and disease-based cohorts, maintain proper organization of these samples, and then to assign these samples to the epigenomic assay pipelines (MethylC-seq, ChIP-seq, RNA-seq, small RNA-seq, genotyping) to generate the reference epigenomes. This involves constant assessment of quality control at multiple stages, until the criteria have been met for reference epigenome standards. The RA will be responsible for the supervision of three research assistants, organizing and prioritizing their schedules. Technology development is also required to assess new methods for sample library preparation. The RA will be required to produce weekly update reports on assay pipelines and related activities within the EMC. The RA will also be involved in primary and higher order analysis of epigenomic data and be expected to contribute to the production of manuscripts.

Qualifications: Ph.D. in genetics, biology, or closely related area and experience in regulatory genomics or epigenomics. Must have 5 years postdoctoral experience in genetics and epigenomics, and at least 0-2 years experience in next-generation sequencing data from epigenomics studies. The ability to manage research assistants and graduate students is a must, as well as experience in handling and organizing large scale experiments. Experience in analyzing large biological data sets coming from next generation sequencing is a must, as is working knowledge of statistics, and the ability to interact and communicate with biologists and bioinformatics.

Duration: This position is for a period of three (3) years and is a non tenure-track position.

Salary: Salary is negotiable, and will be commensurated with qualifications and experience.

Please take note that this is a unionized position covered by the AMURE Collective Agreement.

Applicants should submit a cover letter explaining their qualifications and their interest in this position, a curriculum vita and the names and contact information for three individuals who could provide letters of recommendation. Applications and all inquiries should be sent to The deadline for applications is February 28, 2014.

McGill University is committed to diversity and equity in employment. It welcomes applications from: women, Aboriginal persons, persons with disabilities, ethnic minorities, persons of minority sexual orientation or gender identity, visible minorities, and others who may contribute to diversification. All qualified applicants are encouraged to apply; however, in accordance with Canadian immigration requirements, Canadians and permanent residents will be given priority.


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